Nitric Acid → 1,4-Dimethoxy-2-methyl-5-nitrobenzene

HRID 337363

반응식

HRID 337363 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH3:11].[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:12]([O-:14])=[O:13])[C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH3:11]

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 905522,5-Dimethoxytoluene

생성물 1

HCID 27780951,4-Dimethoxy-2-methyl-5-nitrobenzene수율 96.5%

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

2,5-dimethoxy toluene (6.0 g) was dissolved in acetic acid (20 mL). To the solution, a solution of fuming nitric acid (d=1.50, 4.32 g) in acetic acid (10 mL) was added dropwise at 40° C. over a period of 5 min. The mixture was stirred at 40° C. for 30 min. The reaction mixture was then allowed to cool to room temperature, which was stirred for another 30 min. Then the reaction mixture was diluted with cold water (300 mL). The resulting precipitate was filtered washed with cold water (100 mL) and dried under reduced pressure to afford the title compound (7.5 g).

후처리

  1. temperatureto cool to room temperature
  2. stirringwhich was stirred for another 30 min
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with cold water (100 mL)
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-deeb7964a5b44e7e8abe2dea31a57b0e
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889727B2

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