Bis-(1H-imidazol-2-YL)-methanone → N-((3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)phthalimide, (S)-

HRID 33742노트

반응식

HRID 33742 반응식
[C:1]1(=[O:29])[N:5]([CH2:6][C@H:7]([OH:23])[CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[C:12]([F:22])[CH:11]=2)[C:4](=[O:24])[C:3]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:2]12.[C:30](C1NC=CN=1)(C1NC=CN=1)=[O:31]>C(Cl)Cl>[F:22][C:12]1[CH:11]=[C:10]([N:9]2[CH2:8][C@H:7]([CH2:6][N:5]3[C:4](=[O:24])[C:3]4=[CH:25][CH:26]=[CH:27][CH:28]=[C:2]4[C:1]3=[O:29])[O:23][C:30]2=[O:31])[CH:15]=[CH:14][C:13]=1[N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1

참가 물질

4

반응물 2

HCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 16655949(R)-2-(3-((3-Fluoro-4-morpholinophenyl)amino)-2-hydroxypropyl)isoindoline-1,3-dione

생성물 1

HCID 12973056N-((3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)phthalimide, (S)-수율 79.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-[3-pthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl)aniline (57 gm) is dissolved in methylene dichloride (600 ml), carbonyl diimidazole (32 gm) is added at ambient temperature and the reaction mixture is stirred for 20 hours. The reaction mass is washed with water and methylene dichloride is distilled to give 48 gm of (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide as solid.

후처리

  1. washThe reaction mass is washed with water and methylene dichloride
  2. distillationis distilled

출처 및 근거

ORD 기록
ord-2b95dc978d5f42ef9304f078b3507e96
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429661B2

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