Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 33749생성일: 2026년 10월 23일
Lawesson's reagent → (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione
https://huagongshe.com/ko/reaction/33749
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Lawesson's reagent | HCID 87949 | — |
| 반응물 | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethylfuran-2-yl)-methanone | HCID 11244101 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione | HCID 11508298 | — |
반응 단계
A solution of (4-isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanone (Example 1, 1 equiv.) and Lawesson's reagent (2.1 equiv.) in THF is heated at reflux (70° C.) for 48 h. The reaction is cooled to room temperature and the solvent is removed in vacuo. Chromatography of the residue on a silica gel column using 1-6% 2 M NH3 in MeOH/DCM) provides the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07429659B2 |
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| 출처 데이터셋 | uspto-grants-2008_09 |
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| ORD ID | ord-1110e46f7d2f433e8f777fa8a0a330e1 |
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| 출처 메모 | uspto-grants-2008_09 |
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