Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole → 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole | HCID 10516668 | — |
| 반응물 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 생성물 | 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole | HCID 10491805 | 52.2% |
반응 단계
By the method used in Example 1, Part D, 630 g (2.3 mmol) of 2-cyclopropyl-4-methoxy-1-(phenylmethyl)-1H-indole was O-demethylated by treating it with 9 mL of 1M BBr3 /CH2Cl2. The crude product was chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 316 mg (52% yield) of 2-cyclopropyl-4-hydroxy-1-(phenylmethyl)-1H-indole as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733923 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-90e6c368bccf4e26954b7d2f6022a3b3 |
| 출처 메모 | uspto-grants-1998_03 |