Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminobenzoic Acid → Benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminobenzoic Acid | HCID 978 | — |
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | Cyanoacetamide | HCID 7898 | — |
| 반응물 | Thiophosgene | HCID 10040 | — |
| 반응물 | HCID 178418790 | HCID 178418790 | — |
| 생성물 | Benzimidazole | HCID 5798 | — |
| 생성물 | Benzothiazole | HCID 7222 | — |
| 생성물 | Benzenamine, 4-(2-benzoxazolyl)- | HCID 88733 | — |
| 생성물 | Thiocarbamoyl cyanoacetamide | HCID 13573014 | — |
반응 단계
The 2-(4-aminophenyl)benzoxazole, benzothiazole, or benzimidazole was prepared by condensation of the appropriate aniline derivative with p-amino benzoic acid using polyphosphoric acid. The product was converted to the corresponding isothiocyanate with thiophosgene and subsequently condensed with cyanoacetamide to form the thiocarbamoyl cyanoacetamide. Treatment with bromine afforded the cyano hydroxy thiazole, which was converted to carboxamidine by treatment with the appropriate amide, as shown above.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429667B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-ffad715435b24c70909bdbc409e32c04 |
| 출처 메모 | uspto-grants-2008_09 |