참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,5-Dichlorophenol | HCID 66 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(2,5-Dichloro-phenoxy)-2-fluoro-4-nitro-benzene | HCID 59798046 | 94.7% |
반응 단계
A mixture of 3,4-difluoronitrobenzene (3.2 g, 0.02 mol), 2,5-dichlorophenol (3.59 g, 0.022 mol), and potassium carbonate (3.0 g, 0.022 mol) in 25 ml of anhydrous DMF was heated to 150° C. with stirring overnight. After cooling to room temperature, the reaction mixture was poured into 500 ml of ice water and stirred for 30 min. The precipitates were collected by filtration, washed with water, and dried in vacuo to give 5.72 g (94.7%) of crude product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07429667B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-fafef133eb40479aaefe077d5315a767 |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
