Dimethylformamide → 1,3-Bis(3-methoxypropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

HRID 337613노트

반응식

HRID 337613 반응식
[CH:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)=[O:2].Br[CH2:12][CH2:13][CH2:14][O:15][CH3:16].[CH2:17]1[CH2:27]CN2C(=NCCC2)C[CH2:18]1.CN([CH:31]=[O:32])C>>[CH3:16][O:15][CH2:14][CH2:13][CH2:12][N:7]1[CH:8]=[C:3]([CH:1]=[O:2])[C:4](=[O:10])[N:5]([CH2:18][CH2:17][CH2:27][O:32][CH3:31])[C:6]1=[O:9]

참가 물질

5

반응물 4

HCID 6228DimethylformamideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 3045905-FormyluracilHCID 5245511-Bromo-3-methoxypropane

생성물 1

HCID 866459191,3-Bis(3-methoxypropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

실험 절차

To a DMF (0.35 M) solution of 5-formyluracil (1 eq.) was added sequentially at 0° C. 1-bromo-3-methoxypropane (2.2 eq.) and DBU (2.2 eq.). The resulting solution was stirred at RT for 72 h. The volatiles were then removed in vacuo. The crude product mixture thus obtained was directly subjected to purification by way of column chromatography (SiO2, EtOAc) to afford the title compound as a yellow oil.

후처리

  1. customThe volatiles were then removed in vacuo
  2. customThe crude product mixture thus obtained
  3. customwas directly subjected to purification by way of column chromatography (SiO2, EtOAc)

출처 및 근거

ORD 기록
ord-cde0f4ebe46b4a7b8cbb8028d434ae96
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889714B2

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