4-Chloro-3-methylphenol → HCID 22467254, 화합물

HRID 337618노트

반응식

HRID 337618 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH3:9].C([O-])([O-])=O.[K+].[K+].Br[CH2:17][CH2:18][O:19][CH3:20]>CN(C=O)C.O.CCOCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:17][CH2:18][O:19][CH3:20])=[CH:4][C:3]=1[CH3:9]

참가 물질

7

반응물 3

HCID 17324-Chloro-3-methylphenolHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl ether

생성물 1

HCID 22467254HCID 22467254, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of 4-chloro-3-methylphenol (1 eq.) in DMF (0.7 M) was added K2CO3 (1.2 eq.). The mixture was stirred at 50° C. for 5 min before 1-bromo-2-methoxyethane (1.5 eq.) was added. After 2 h at 70° C., the reaction mixture was cooled down to RT and then diluted with water and ether. The organic phase was separated and washed sequentially with 2 N aq. NaOH, water and brine. The organic extract was dried over Na2SO4, filtered and the filtrate concentrated in vacuo to afford the title compound as a yellowish oil.

후처리

  1. additionwas added
  2. customThe organic phase was separated
  3. washwashed sequentially with 2 N aq. NaOH, water and brine
  4. extractionThe organic extract
  5. dry with materialwas dried over Na2SO4
  6. filtrationfiltered
  7. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-ce8696ec85d046e4b4bc07a5a4c1936d
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889714B2

반응 노트

불러오는 중…