2-Aminopropanol → HCID 178460296, 화합물

HRID 33767

반응식

HRID 33767 반응식
[N:1]1(C(C2C=C(NC3(O)C(C(=N)NC(C)CO)=CSN3)C=CC=2)=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.N1([C:41]([C:43]2[CH:48]=[CH:47][C:46]([NH:49][C:50]3[S:54][N:53]=[C:52]([OH:55])[C:51]=3[C:56]#[N:57])=[CH:45][CH:44]=2)=[O:42])C2C(=CC=CC=2)CC1.[NH2:58][CH:59]([CH3:62])[CH2:60][OH:61]>CCO>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([C:41]([C:43]2[CH:44]=[CH:45][C:46]([NH:49][C:50]3[S:54][N:53]=[C:52]([OH:55])[C:51]=3[C:56]([NH:58][CH:59]([CH3:62])[CH2:60][OH:61])=[NH:57])=[CH:47][CH:48]=2)=[O:42])[CH2:2]1

참가 물질

5

반응물 3

HCID 51262-AminopropanolHCID 178460299HCID 178460299, 화합물HCID 178510530HCID 178510530, 화합물

생성물 1

HCID 178460296HCID 178460296, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

5-[3-(3-(1H-indole-1-carbonyl)phenylamino]-3-hydroxy-N-(1-hydroxypropan-2-yl)isothiazole-4-carboximidamide 6: 5-[3-(3-(1H-indole-1-carbonyl)phenylamino]-3-hydroxyisothaizole-4-carbonitrile 5: (0.362 gm, 1 mmol) was taken into anhydrous EtOH (10 ml) and to this 2-amino-propan-1-ol (0.375 gm, 5 mmol) was added. The reaction mixture was stirred at 80° C. for 16 h., then concentrated to dryness and purified by column chromatography to provide 5-[4-(2,3-dihydro-indole-1-carbonyl)-phenylamino]-3-hydroxy-N-(2-hydroxy-1-methyl-ethyl)-isothiazole-4-carboxamidine 6.

후처리

  1. additionwas added
  2. concentrationconcentrated to dryness
  3. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-448d33eadda545649617d500921c9522
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429667B2

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