N,N,N',N'-Tetramethylethylenediamine → (1S*,2R*)-2-(1-Methyl-1H-pyrazol-5-yl)cycloheptanol
반응식
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[N:3]1.CN(C)CCN(C)C.C([Li])CCC.[O:20]1[CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH:21]12>C1COCC1>[CH3:1][N:2]1[C:6]([C@H:22]2[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C@@H:21]2[OH:20])=[CH:5][CH:4]=[N:3]1참가 물질
6
실험 절차
The reaction and aftertreatment were conducted in the same manner as in Example 4a by using 1-methylpyrazole (3.66 g, 44.6 mmol), N,N,N′,N′-tetramethylethylenediamine (6.68 mL, 44.6 mmol), n-butyl lithium (1.63 M solution in hexane; 32 mL, 52.2 mmol), 1,2-epoxycycloheptane (5.0 g, 44.6 mmol) and THF (60 mL), to yield the title compound (1.13 g, 13%) as a colorless oil.
후처리
- customThe reaction and aftertreatment
출처 및 근거
- ORD 기록
- ord-3fc117bbd9d64ddd9db3c5e6f0369bf5
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889741B2
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