Dabco → HCID 89963165, 화합물

HRID 337737

반응식

HRID 337737 반응식
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][N:8]=1.[Cl:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[S:28](Cl)(=[O:30])=[O:29].N12CCN(CC1)CC2>C(#N)C>[Cl:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([F:27])=[CH:22][C:21]=1[S:28]([N:6]([CH2:5][C:4]1[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=1[O:2][CH3:1])[C:7]1[CH:12]=[CH:11][N:10]=[CH:9][N:8]=1)(=[O:30])=[O:29]

참가 물질

5

반응물 3

HCID 9237DabcoHCID 27735232-Chloro-4,5-difluorobenzenesulfonyl chlorideHCID 63362995N-(2,4-Dimethoxybenzyl)pyrimidin-4-amine

생성물 1

HCID 89963165HCID 89963165, 화합물수율 21.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The reaction and aftertreatment were conducted in the same manner as in Example 14b by using the N-(2,4-dimethoxybenzyl)pyrimidin-4-amine (150 mg, 0.611 mmol) prepared in Example 14a, 2-Chloro-4,5-difluorobenzenesulfonyl chloride (302 mg, 1.22 mmol), 1,4-diazabicyclo[2.2.2]octane (137 mg, 1.22 mmol) and acetonitrile (5.0 mL), to yield the title compound (58.8 mg, 21%) as a colorless oil.

후처리

  1. customThe reaction and aftertreatment

출처 및 근거

ORD 기록
ord-1321217a95e34d0eb753de3bf97c059c
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889741B2

연결된 노트

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