2,4-Difluoropyrimidine → N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amine

HRID 337747

반응식

HRID 337747 반응식
[F:1][C:2]1[N:7]=[C:6](F)[CH:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:12]=1[CH2:13][NH2:14]>C1COCC1>[CH3:9][O:10][C:11]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:12]=1[CH2:13][NH:14][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([F:1])[N:7]=1

참가 물질

4

반응물 2

HCID 1377162,4-DifluoropyrimidineHCID 5972502,4-Dimethoxybenzylamine

생성물 1

HCID 89963279N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amine수율 43.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2,4-difluoropyrimidine (600 mg, 5.17 mmol) and 2,4-dimethoxybenzylamine (860 mg, 5.17 mmol) in THF (17 mL) was stirred at room temperature for 1 hour. The reaction solution was vacuum concentrated, and the residue was then purified with silica gel chromatography (hexane/ethyl acetate=1:2) to yield the title compound (594 mg, 43%) as a colorless solid.

후처리

  1. concentrationconcentrated
  2. customthe residue was then purified with silica gel chromatography (hexane/ethyl acetate=1:2)

출처 및 근거

ORD 기록
ord-79be105280ff431aa99862a817d27c50
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889741B2

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