Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hexamethyldisilazide → N-(2,4-dimethoxybenzyl)-2,4,5-trifluoro-N-(2-fluoropyrimidin-4-yl)benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 반응물 | 2,4,5-Trifluorobenzenesulfonyl chloride | HCID 2776979 | — |
| 반응물 | N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amine | HCID 89963279 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(2,4-dimethoxybenzyl)-2,4,5-trifluoro-N-(2-fluoropyrimidin-4-yl)benzenesulfonamide | HCID 89962306 | 63.3% |
반응 단계
The reaction and aftertreatment were conducted in the same manner as in Example 15a by using the N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amine (0.20 g, 0.76 mmol) prepared in Example 24a, LiHMDS (1.0 M in THF, 0.91 mL, 0.91 mmol), 2,4,5-trifluorobenzenesulfonyl chloride (0.19 g, 0.84 mmol) and THF (3.0 mL), to yield the title compound (0.22 g, 63%) as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889741B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-c080981990e64642bd29a8453a34e9a2 |
| 출처 메모 | uspto-grants-2014_11 |