Cesium carbonate → HCID 89962119, 화합물

HRID 337842

반응식

HRID 337842 반응식
CC1(C)C(C)(C)OB([C:9]2[C:10]3([CH2:15][CH2:16][CH2:17][CH:18]=2)[O:14][CH2:13][CH2:12][O:11]3)O1.Br[C:21]1[CH:26]=[C:25]([Cl:27])[N:24]=[N:23][C:22]=1[NH2:28].C(=O)([O-])[O-].[Cs+].[Cs+].O1CCOCC1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O>[Cl:27][C:25]1[N:24]=[N:23][C:22]([NH2:28])=[C:21]([C:9]2[C:10]3([CH2:15][CH2:16][CH2:17][CH:18]=2)[O:11][CH2:12][CH2:13][O:14]3)[CH:26]=1

참가 물질

7

반응물 4

HCID 10796Cesium carbonateHCID 312751,4-DioxaneHCID 220244193-Amino-4-bromo-6-chloropyridazineHCID 89963451HCID 89963451, 화합물

생성물 1

HCID 89962119HCID 89962119, 화합물수율 43%

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 962Water용매

실험 절차

The reaction and aftertreatment were conducted in the same manner as in Example 39a by using the 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]dec-6-ene (0.64 g, 2.40 mmol) prepared in Example 82a, 4-bromo-6-chloropyridazin-3-amine (0.50 g, 2.40 mmol), tetrakis(triphenylphosphine)palladium (0) (0.14 g, 0.12 mmol), cesium carbonate (1.72 g, 5.29 mmol), dioxane (8.0 mL) and water (4.0 mL), to yield the title compound (275.7 mg, 43%) as a colorless oil.

후처리

  1. customThe reaction and aftertreatment

출처 및 근거

ORD 기록
ord-4e8760d21a7944e6a9304d36acc17e4a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889741B2

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