Chloromethyl Methyl Ether → HCID 89963013, 화합물
반응식
[NH:1]1[CH:5]=[C:4]([C@@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@H:7]2[OH:12])[CH:3]=[N:2]1.[CH3:13][O:14][CH2:15]Cl>CN(C=O)C>[CH3:13][O:14][CH2:15][N:1]1[CH:5]=[C:4]([C@@H:6]2[CH2:11][CH2:10][CH2:9][CH2:8][C@H:7]2[OH:12])[CH:3]=[N:2]1참가 물질
4
실험 절차
To a solution of the (1R,2S)-2-(1H-pyrazol-4-yl)cyclohexanol (170 mg, 1.02 mmol) prepared in Example 169b in DMF (5.0 mL), chloromethyl methyl ether (0.078 mL, 1.02 mmol) was added, and the reaction solution was stirred at room temperature for 2 hours. The reaction solution was vacuum concentrated, and the residue was then purified with silica gel chromatography (hexane/ethyl acetate=7:3) to yield the title compound (132 mg, 61%) as a colorless solid.
후처리
- concentrationconcentrated
- customthe residue was then purified with silica gel chromatography (hexane/ethyl acetate=7:3)
출처 및 근거
- ORD 기록
- ord-4ba879dbb1574a0491c8f5f3d7caa458
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889741B2
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