Dimethylformamide → 2,6-Diisopropyl-4-bromobenzaldehyde

HRID 338210노트

반응식

HRID 338210 반응식
I[C:2]1[C:7]([CH:8]([CH3:10])[CH3:9])=[CH:6][C:5]([Br:11])=[CH:4][C:3]=1[CH:12]([CH3:14])[CH3:13].[Li]CCCC.CN([CH:23]=[O:24])C>C1(C)C=CC=CC=1>[CH:12]([C:3]1[CH:4]=[C:5]([Br:11])[CH:6]=[C:7]([CH:8]([CH3:10])[CH3:9])[C:2]=1[CH:23]=[O:24])([CH3:14])[CH3:13]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 574376675-Bromo-2-iodo-1,3-diisopropylbenzeneHCID 178418339Butyllithium

생성물 1

HCID 574376682,6-Diisopropyl-4-bromobenzaldehyde

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

A 150 mL of dry toluene solution of 1-iodo-2,6-diisopropyl-4-bromobenzene (17.6 g, 0.048 mol) was treated with n-BuLi (1.6 M in hexane, 75 mL) at −78° C. in 30 minutes. After stirring for 15 minutes, dry DMF (20 mL) in 50 mL of toluene was added dropwise. The resulting mixture was slowly warmed up to room temperature. After regular work up, the crude product was distilled at 140° C. under vacuum to afford 2,6-diisopropyl-4-bromobenzaldehyde (11.5 g).

후처리

  1. distillationAfter regular work up, the crude product was distilled at 140° C. under vacuum

출처 및 근거

ORD 기록
ord-92f6288e6b3842dd9f76fc58992d3efd
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889864B2

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