4-Bromophenol → 3-(4-Bromophenoxy)propan-1-ol
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][CH2:12][OH:13].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][CH2:12][OH:13])=[CH:4][CH:3]=1참가 물질
5
실험 절차
To a solution of 4-bromophenol (10 g, 58 mmol) in DMF (10 mL) was added 3-bromopropan-1-ol (9.6 g, 69 mmol) and potassium carbonate (13.6 g, 98 mmol). The mixture was stirred at room temperature for 12 h. LCMS showed the reaction was almost complete. The mixture was partitioned between water and ethyl acetate (20 mL×3), The combined organics were dried and concentrated to give the title compound that was used in the next step without further purification (14.7 g, quant). 1H NMR (400 MHz, CD3OD) δ 7.36 (d, 2H), 6.84 (d, 2H), 4.05 (t, 2H), 3.72 (t, 2H), 1.96 (m, 2H).
후처리
- customThe mixture was partitioned between water and ethyl acetate (20 mL×3)
- customThe combined organics were dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-7f54d6a6cb7b4c4b8b0c3ed45624452f
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889730B2
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