7-Chloro-2-(chloromethyl)quinoline → 7-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chloride

HRID 33844

반응식

HRID 33844 반응식
COC(=O)C1C=CC(OCC2C=CC3C(=CC=CC=3)N=2)=CC=1.[CH3:23][N:24]1[CH:28]=[C:27]([C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[C:26]([C:35]2[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=2)=[N:25]1.[Cl:42][C:43]1[CH:52]=[C:51]2[C:46]([CH:47]=[CH:48][C:49]([CH2:53]Cl)=[N:50]2)=[CH:45][CH:44]=1>>[ClH:42].[Cl:42][C:43]1[CH:52]=[C:51]2[C:46]([CH:47]=[CH:48][C:49]([CH2:53][O:41][C:38]3[CH:39]=[CH:40][C:35]([C:26]4[C:27]([C:29]5[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=5)=[CH:28][N:24]([CH3:23])[N:25]=4)=[CH:36][CH:37]=3)=[N:50]2)=[CH:45][CH:44]=1

참가 물질

4

반응물 3

HCID 109548447-Chloro-2-(chloromethyl)quinolineHCID 19934817Methyl 4-(2-quinolinylmethoxy)benzoateHCID 1359152134-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]Phenol

생성물 1

HCID 115617317-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chloride

실험 절차

Following the procedure for the preparation of 4-(Quinolin-2-ylmethoxy)-benzoic acid methyl ester but substituting 4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenol and 7-chloro-2-chloromethyl-quinoline provided the title compound. 1H NMR (400 MHz, DMSO) δ 8.66 (d, J=6.6 Hz, 2H), 8.54 (s, 1 H), 8.47 (d, J=8.3, 2H), 8.04 (m, 2H), 7.70 (m, 2H), 7.65 (m, 1H), 7.36 (d, J=8.7 Hz, 2H), 7.12 (d, J=8.7, 2H), 5.38 (s, 2H), 3.90 (s, 3 H); MS: (M+H m/z=427.1).

출처 및 근거

ORD 기록
ord-691d24d58cb347c197930b510ed1a33c
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429665B2

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