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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 33845생성일: 2026년 10월 25일

2-(Chloromethyl)-6-fluoroquinoline → 6-Fluoro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chloride

https://huagongshe.com/reaction/33845

반응식

참여 물질

역할이름HCID투입량
반응물2-(Chloromethyl)-6-fluoroquinolineHCID 11241007—
반응물7-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chlorideHCID 11561731—
생성물6-Fluoro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chlorideHCID 11669506—

반응 단계

Following the procedure for the preparation of 7-Chloro-2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrogen chloride but substituting 2-chloromethyl-6-fluoro-quinoline provided the title compound. 1H NMR (400 MHz, DMSO) δ 8.67 (d, J=6.6 Hz, 2H), 8.55 (s, 1 H), 8.42 (d, J=8.3, 1H), 8.04 (m, 1H), 7.82 (m, 1H), 7.71 (m, 4H), 7.36 (d, J=8.7 Hz, 2H), 7.12 (d, J=8.7, 2H), 5.37 (s, 2H), 3.91 (s, 3 H); MS: (M+H m/z=411.2).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07429665B2
출처 데이터셋uspto-grants-2008_09
ORD IDord-18465de22eed4295b574d47f43af8c18
출처 메모uspto-grants-2008_09