4-Bromo-2-fluorobenzaldehyde → 4-Bromo-2-methoxybenzaldehyde

HRID 338504

반응식

HRID 338504 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH3:11][O-:12].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:12][CH3:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 1435174-Bromo-2-fluorobenzaldehydeHCID 10942334Sodium Methoxide

생성물 1

HCID 110530414-Bromo-2-methoxybenzaldehyde수율 97.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The mixture of 4-bromo-2-fluorobenzaldehyde (6.1 g, 0.03 mol) and sodium methoxide (1.78 g, 0.033 mol) in dry methanol (60 mL) was stirred at reflux for 16 hours. The methanol was evaporated. The residue was partitioned between DCM and water. The organic layers were dried over sodium sulfate, concentrated in vacuo to give a yellow solid, which was purified by silica gel chromatography (Petroleum ether/EtOAc=20:1 to 10:1) to give the title compound (6.3 g, 97%) as a light yellow solid.

후처리

  1. temperatureat reflux for 16 hours
  2. customThe methanol was evaporated
  3. customThe residue was partitioned between DCM and water
  4. dry with materialThe organic layers were dried over sodium sulfate
  5. concentrationconcentrated in vacuo
  6. customto give a yellow solid, which
  7. customwas purified by silica gel chromatography (Petroleum ether/EtOAc=20:1 to 10:1)

출처 및 근거

ORD 기록
ord-355bd356a8c4475d89d84dbd5e6720e9
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889730B2

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