2-(Pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)ethan-1-one → 1-[2,3-Difluoro-4-(quinolin-2-ylmethoxy)-phenyl]-2-pyridin-4-yl-ethanone

HRID 33851

반응식

HRID 33851 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7]C(C2C=CC(OCC3C=CC4C(=CC=CC=4)N=3)=CC=2)=O)=[CH:3][CH:2]=1.[F:28][C:29]1[C:40]([F:41])=[C:39]([O:42][CH2:43][C:44]2[CH:53]=[CH:52][C:51]3[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=3)[N:45]=2)[CH:38]=[CH:37][C:30]=1[C:31](N(OC)C)=[O:32]>>[F:28][C:29]1[C:40]([F:41])=[C:39]([O:42][CH2:43][C:44]2[CH:53]=[CH:52][C:51]3[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=3)[N:45]=2)[CH:38]=[CH:37][C:30]=1[C:31](=[O:32])[CH2:7][C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1

참가 물질

3

반응물 2

HCID 336797272-(Pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)ethan-1-oneHCID 862492832,3-Difluoro-N-methoxy-N-methyl-4-(quinolin-2-ylmethoxy)-benzamide

생성물 1

HCID 685755071-[2,3-Difluoro-4-(quinolin-2-ylmethoxy)-phenyl]-2-pyridin-4-yl-ethanone

실험 절차

Following the procedure for the preparation of 2-pyridin-4-yl-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone but substituting 2,3-Difluoro-N-methoxy-N-methyl-4-(quinolin-2-ylmethoxy)-benzamide provided the title compound. MS: (M+H m/z=391.1).

출처 및 근거

ORD 기록
ord-09cd0a1e86af4e3b9f3f7aa730036eb6
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429665B2

연결된 노트

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