4-Bromo-2-fluorobenzaldehyde → 4-Bromo-2-methoxybenzaldehyde

HRID 338516노트

반응식

HRID 338516 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH3:11][O-:12].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([O:12][CH3:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 1435174-Bromo-2-fluorobenzaldehydeHCID 10942334Sodium Methoxide

생성물 1

HCID 110530414-Bromo-2-methoxybenzaldehyde수율 94.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-bromo-2-fluorobenzaldehyde (25.0 g, 0.123 mol) and sodium methoxide (13.99 g, 0.2600 mol) in dry methanol (250 mL) was stirred at reflux temperature for 16 hours. The mixture was concentrated and the residue was partitioned between dichloromethane (500 mL) and water (250 mL). The organic layers were combined and dried over sodium sulfate then concentrated in vacuo to provide the title compound as yellow solid (25 g, 94.5%).

후처리

  1. temperatureat reflux temperature for 16 hours
  2. concentrationThe mixture was concentrated
  3. customthe residue was partitioned between dichloromethane (500 mL) and water (250 mL)
  4. dry with materialdried over sodium sulfate
  5. concentrationthen concentrated in vacuo

출처 및 근거

ORD 기록
ord-f10ddf9e31c6467c9c7d5611ebcdeb79
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889730B2

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