Water → 3-Bromo-6-chloro-2-methoxypyridine
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[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH3:10][O-:11].[Na+].O>C(#N)C>[Br:1][C:2]1[C:3]([O:11][CH3:10])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1참가 물질
5
실험 절차
To a solution of 3-bromo-2,6-dichloropyridine (3.00 g, 13.2 mmol) in acetonitrile (20 mL) was added sodium methoxide (methanol solution, 4.83 mol/L, 3.0 mL) dropwise at 0° C. The mixture was stirred at room temperature over night. To the mixture was added 30 mL of water, and the organic was evaporated. The resulting suspension was filtered, and the pad was washed with water for several times. The pad was dried under reduce pressure to give title compound (2.74 g, 93.2%) as white solid.
후처리
- customthe organic was evaporated
- filtrationThe resulting suspension was filtered
- washthe pad was washed with water for several times
- customThe pad was dried
출처 및 근거
- ORD 기록
- ord-9c9d8474c4a8480f968ef626d4d6ae74
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889730B2
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