참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | (4-(Benzyloxy)phenyl)hydrazine monohydrochloride | HCID 3016725 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(4-Benzyloxy-phenyl-2H-pyrazol-3-yl]-pyridine | HCID 86606416 | — |
반응 단계
To a solution of 3-Dimethylamino-1-pyridin-4-yl-propenone (590 mg) in methanol (10 ml) was added acetic acid (0.5 ml) and (4-Benzyloxy-phenyl)-hydrazine hydrogen chloride (836 mg) and the reaction mixture heated to 60° C. for 6 h. The reaction mixture was poured into saturated sodium bicarbonate, extracted with ethyl acetate, dried magnesium sulfate, filtered and concentrated. Purification via combiflash MPLC provided the title compound (795 mg). MS: (M+H m/z=328.1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07429665B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-59dbb7e24d53454c96698a6b1ff946d5 |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
