3-(Trifluoromethyl)aniline → 3-Bromo-5-methyl-N-[3-(trifluoromethyl)phenyl]benzamide

HRID 338741노트

반응식

HRID 338741 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([OH:7])=O.[F:12][C:13]([F:22])([F:21])[C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([NH:17][C:16]1[CH:18]=[CH:19][CH:20]=[C:14]([C:13]([F:12])([F:21])[F:22])[CH:15]=1)=[O:7]

참가 물질

3

반응물 2

HCID 73753-(Trifluoromethyl)anilineHCID 34331273-Bromo-5-methylbenzoic acid

생성물 1

HCID 866958593-Bromo-5-methyl-N-[3-(trifluoromethyl)phenyl]benzamide수율 58%

실험 절차

In a manner similar to that described in Preparation 41, 3-bromo-5-methylbenzoic acid (400 mg) and 3-(trifluoromethyl)aniline were converted to the title compound (388 mg, 58%).

출처 및 근거

ORD 기록
ord-bfeb45ed23ae4643a598abc3ecdd6c94
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889870B2

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