Methyl 3-chloro-4-hydroxybenzoate → 3-Chloro-4-(quinolin-2-ylmethoxy)-benzoic acid methyl ester

반응식

[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)=[CH:6][CH:5]=1.COC(=O)C1C=CC(O)=C([Cl:33])C=1>>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)=[C:6]([Cl:33])[CH:5]=1

참가 물질

반응물 2

HCID 77580Methyl 3-chloro-4-hydroxybenzoate

HCID 19934817Methyl 4-(2-quinolinylmethoxy)benzoate

생성물 1

HCID 685759083-Chloro-4-(quinolin-2-ylmethoxy)-benzoic acid methyl ester

실험 절차

Following the procedure for the preparation of 4-(Quinolin-2-ylmethoxy)-benzoic acid methyl ester but substituting 3-Chloro-4-hydroxy-benzoic acid methyl ester provided the title compound. MS: (M+H m/z=328.0).

출처 및 근거

ORD 기록: ord-b99e42df3b7642b2b299de74d9b75ce1
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07429665B2

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