3,5-Dibromo-4-Hydroxybenzaldehyde → 2,6-Dibromo-4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenol

HRID 338787

반응식

HRID 338787 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:11])[C:9]=1[OH:10])[CH:5]=O.[NH2:12][C:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:14]=1[SH:23]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2[S:23][C:14]3[CH:15]=[CH:16][C:17]([C:19]([F:20])([F:21])[F:22])=[CH:18][C:13]=3[N:12]=2)[CH:7]=[C:8]([Br:11])[C:9]=1[OH:10]

참가 물질

4

반응물 2

HCID 181003,5-Dibromo-4-HydroxybenzaldehydeHCID 880422-Amino-4-(trifluoromethyl)benzenethiol

생성물 1

HCID 1361834942,6-Dibromo-4-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)phenol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

In a N,N-dimethylformamide (DMF) solvent, a suspension of 3,5-dibromo-4-hydroxybenzaldehyde (1.0 eq.) and 2-amino-4-(trifluoromethyl)benzenethiol (1.0 eq.) was heated at a temperature of 100° C. After cooling, DMF was removed therefrom under reduced pressure. Methylene chloride was added to the resultant solid, and the produced precipitate was filtered, and washed with methylene chloride to obtain a solid target product.

후처리

  1. temperatureAfter cooling
  2. customDMF was removed
  3. additionMethylene chloride was added to the resultant solid
  4. filtrationthe produced precipitate was filtered
  5. washwashed with methylene chloride
  6. customto obtain a solid target product

출처 및 근거

ORD 기록
ord-b681226bcc2444e1987d034dffcf3148
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889881B2

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