Hydrazine → Methyl 6-hydrazinylpyridine-3-carboxylate

HRID 338847노트

반응식

HRID 338847 반응식
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[NH2:12][NH2:13]>C1COCC1>[NH:12]([C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1)[NH2:13]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 13758765Methyl 6-fluoropyridine-3-carboxylate

생성물 1

HCID 55280209Methyl 6-hydrazinylpyridine-3-carboxylate수율 89.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of methyl 6-fluoronicotinate (13.9 g, 89.60 mmol) and hydrazine (5.625 ml, 179.2 mmol) in THF (200 mL) were heated at 56° C. for 2 hours. After cooling to ambient temperature, the solvent was removed under reduced pressure and water (200 mL) was added. The suspension was stirred at ambient temperature for 1 hour. The solid was collected by filtration, washed with water and dried to give methyl 6-hydrazinylnicotinate (13.4 g, 89.5%) as a solid.

후처리

  1. customthe solvent was removed under reduced pressure and water (200 mL)
  2. additionwas added
  3. filtrationThe solid was collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-c937c3d86bc743d4970c90d94f93d68f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889704B2

반응 노트

불러오는 중…