1,4-Dioxane → Methyl 2-formylquinoline-7-carboxylate
반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][CH:8]=2)[N:3]=1.[O:16]1CCOCC1>O>[CH:1]([C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][CH:8]=2)[N:3]=1)=[O:16]참가 물질
4
실험 절차
To a solution of methyl 2-methylquinoline-7-carboxylate (0.99 g, 4.92 mmol) in dioxane (60 mL) and water (0.6 mL) was added SeO2 (0.66 g, 5.90 mmol) and the mixture was stirred at reflux for 2 hours. After cooling to ambient temperature, the solid was removed by filtration and washed with DCM. The filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (1:4 hexane/ethyl acetate) to give methyl 2-formylquinoline-7-carboxylate (0.75 g, 70.8%) as a solid.
후처리
- temperatureat reflux for 2 hours
- customthe solid was removed by filtration
- washwashed with DCM
- concentrationThe filtrate was concentrated under reduced pressure
- customThe residue was purified by flash chromatography on silica gel (1:4 hexane/ethyl acetate)
출처 및 근거
- ORD 기록
- ord-c2d880793db94ae6b978fb0d7ffb8609
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889704B2
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