1,4-Dioxane → 72804-91-2

HRID 338867노트

반응식

HRID 338867 반응식
[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([CH3:13])[CH:9]=[CH:8]2)[CH3:2].[O:14]1CCOCC1>O>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([CH:13]=[O:14])[CH:9]=[CH:8]2)[CH3:2]

참가 물질

4

반응물 2

HCID 312751,4-DioxaneHCID 144752508-Ethyl-2-methylquinoline

생성물 1

HCID 1269983472804-91-2수율 85.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 8-ethyl-2-methylquinoline (3.34 g, 19.5 mmol) in dioxane (150 mL) and water (1.5 mL) was added SeO2 (2.60 g, 23.4 mmol) and the mixture was stirred at reflux for 2 hours. After cooling to ambient temperature, the solid was removed by filtration and washed with DCM. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel (1:1 hexane/DCM) to give 8-ethylquinoline-2-carbaldehyde (3.1 g, 85.8%) as a solid.

후처리

  1. temperatureat reflux for 2 hours
  2. customthe solid was removed by filtration
  3. washwashed with DCM
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customthe residue was purified by flash chromatography on silica gel (1:1 hexane/DCM)

출처 및 근거

ORD 기록
ord-917b3a8ce8664f37b43843fb55db1307
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889704B2

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