tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate → tert-butyl N-[(3S)-1-[(1R)-2,2,2-trifluoro-1-[6-[(2E)-2-[(6-fluoro-7-methoxyquinolin-2-yl)methylidene]hydrazinyl]-3-pyridinyl]ethyl]pyrrolidin-3-yl]carbamate

HRID 338911노트

반응식

HRID 338911 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[C:7]([CH:14]=O)[CH:6]=[CH:5]2.[F:16][C:17]([F:41])([F:40])[C@H:18]([N:27]1[CH2:31][CH2:30][C@H:29]([NH:32][C:33](=[O:39])[O:34][C:35]([CH3:38])([CH3:37])[CH3:36])[CH2:28]1)[C:19]1[CH:20]=[N:21][C:22]([NH:25][NH2:26])=[CH:23][CH:24]=1>C(O)C>[F:40][C:17]([F:16])([F:41])[C@H:18]([N:27]1[CH2:31][CH2:30][C@H:29]([NH:32][C:33](=[O:39])[O:34][C:35]([CH3:37])([CH3:38])[CH3:36])[CH2:28]1)[C:19]1[CH:20]=[N:21][C:22]([NH:25]/[N:26]=[CH:14]/[C:7]2[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][C:11]([O:12][CH3:13])=[C:2]([F:1])[CH:3]=3)[N:8]=2)=[CH:23][CH:24]=1

참가 물질

4

반응물 2

HCID 86707414tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamateHCID 867074436-Fluoro-7-methoxyquinoline-2-carbaldehyde

생성물 1

HCID 140629013tert-butyl N-[(3S)-1-[(1R)-2,2,2-trifluoro-1-[6-[(2E)-2-[(6-fluoro-7-methoxyquinolin-2-yl)methylidene]hydrazinyl]-3-pyridinyl]ethyl]pyrrolidin-3-yl]carbamate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 6-fluoro-7-methoxyquinoline-2-carbaldehyde (54.7 mg, 0.266 mmol) in ethanol (5 mL) was added tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate (100 mg, 0.266 mmol) and the reaction was stirred for 24 hours at ambient temperature. The reaction was concentrated to dryness and used as is in the next step.

후처리

  1. concentrationThe reaction was concentrated to dryness

출처 및 근거

ORD 기록
ord-d91909cb26f6410fabe1fbf5fcd54bbc
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889704B2

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