tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate → tert-butyl N-[(3S)-1-[(1R)-2,2,2-trifluoro-1-[6-[(2E)-2-[[7-(2-methoxyethoxy)-8-methylquinolin-2-yl]methylidene]hydrazinyl]pyridin-3-yl]ethyl]pyrrolidin-3-yl]carbamate

HRID 338924노트

반응식

HRID 338924 반응식
[F:1][C:2]([F:26])([F:25])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10][NH2:11])=[CH:8][CH:9]=1.[CH3:27][O:28][CH2:29][CH2:30][O:31][C:32]1[C:41]([CH3:42])=[C:40]2[C:35]([CH:36]=[CH:37][C:38]([CH:43]=O)=[N:39]2)=[CH:34][CH:33]=1>C(O)C>[F:26][C:2]([F:25])([F:1])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:23])[CH3:21])[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10]/[N:11]=[CH:43]/[C:38]2[CH:37]=[CH:36][C:35]3[C:40](=[C:41]([CH3:42])[C:32]([O:31][CH2:30][CH2:29][O:28][CH3:27])=[CH:33][CH:34]=3)[N:39]=2)=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 86707414tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamateHCID 867074527-(2-Methoxyethoxy)-8-methylquinoline-2-carbaldehyde

생성물 1

HCID 140628976tert-butyl N-[(3S)-1-[(1R)-2,2,2-trifluoro-1-[6-[(2E)-2-[[7-(2-methoxyethoxy)-8-methylquinolin-2-yl]methylidene]hydrazinyl]pyridin-3-yl]ethyl]pyrrolidin-3-yl]carbamate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

tert-Butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate (98.0 mg, 0.261 mmol) and 7-(2-methoxyethoxy)-8-methylquinoline-2-carbaldehyde (64 mg, 0.261 mmol) were stirred in ethanol at ambient temperature for 24 hours. The reaction was concentrated and used as is in the next step.

후처리

  1. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-ac2e2b853a334949a094bddf3df37f07
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889704B2

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