tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate → tert-butyl N-[(3S)-1-[(1R)-1-[6-[(2E)-2-[(7-ethoxy-6-fluoroquinolin-2-yl)methylidene]hydrazinyl]pyridin-3-yl]-2,2,2-trifluoroethyl]pyrrolidin-3-yl]carbamate

HRID 338947노트

반응식

HRID 338947 반응식
[F:1][C:2]([F:26])([F:25])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10][NH2:11])=[CH:8][CH:9]=1.[CH2:27]([O:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[CH:35][C:36]([CH:40]=O)=[N:37]2)=[CH:32][C:31]=1[F:42])[CH3:28]>C(O)C>[CH2:27]([O:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[CH:35][C:36](/[CH:40]=[N:11]/[NH:10][C:7]3[N:6]=[CH:5][C:4]([C@@H:3]([N:12]4[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:23])[CH3:21])[CH2:13]4)[C:2]([F:25])([F:1])[F:26])=[CH:9][CH:8]=3)=[N:37]2)=[CH:32][C:31]=1[F:42])[CH3:28]

참가 물질

4

반응물 2

HCID 86707414tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamateHCID 867074687-Ethoxy-6-fluoroquinoline-2-carbaldehyde

생성물 1

HCID 140628984tert-butyl N-[(3S)-1-[(1R)-1-[6-[(2E)-2-[(7-ethoxy-6-fluoroquinolin-2-yl)methylidene]hydrazinyl]pyridin-3-yl]-2,2,2-trifluoroethyl]pyrrolidin-3-yl]carbamate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate (240 mg, 0.639 mmol) and 7-ethoxy-6-fluoroquinoline-2-carbaldehyde (140 mg, 0.639 mmol) in ethanol (5 mL) were stirred at ambient temperature for 24 hours. After concentration, the residue was used in the next step without purification.

후처리

  1. concentrationAfter concentration
  2. customthe residue was used in the next step without purification

출처 및 근거

ORD 기록
ord-bb48c85ad0034f028fb97feaae159c36
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889704B2

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