1,4-Dioxane → 7-(Oxetan-3-yl)quinoline-2-carbaldehyde

HRID 339078노트

반응식

HRID 339078 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][C:6]([CH:12]3[CH2:15][O:14][CH2:13]3)=[CH:7][CH:8]=2)[N:3]=1.[O:16]1CCOCC1>O>[O:14]1[CH2:13][CH:12]([C:6]2[CH:5]=[C:4]3[C:9]([CH:10]=[CH:11][C:2]([CH:1]=[O:16])=[N:3]3)=[CH:8][CH:7]=2)[CH2:15]1

참가 물질

4

반응물 2

HCID 312751,4-DioxaneHCID 867075512-Methyl-7-(oxetan-3-yl)quinoline

생성물 1

HCID 867075527-(Oxetan-3-yl)quinoline-2-carbaldehyde수율 93.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Methyl-7-(oxetan-3-yl)quinoline (0.020 g, 0.100 mmol) was dissolved in dioxane (5 mL) and water (0.05 mL). The reaction was treated with SeO2 (0.013 g, 0.120 mmol) and the mixture was heated to reflux for 2 hours. After cooling to ambient temperature, the solid was removed by filtration and washed with DCM. The filtrate was concentrated under reduced pressure to give 7-(oxetan-3-yl)quinoline-2-carbaldehyde (0.020 g, 0.0938 mmol, 93.4% yield) as a solid.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 2 hours
  3. customthe solid was removed by filtration
  4. washwashed with DCM
  5. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8a3a255a5aaa4105b2c3fb296f73aa21
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889704B2

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