Diethyl Ether → HCID 178496224, 화합물

HRID 339165

반응식

HRID 339165 반응식
[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N+:9]1[C:17]2[C:12](=[CH:13][C:14]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:15][CH:16]=2)[C:11]([CH3:29])([CH2:22][CH2:23][CH2:24][S:25]([OH:28])(=[O:27])=[O:26])[C:10]=1/[CH:30]=[CH:31]/NC1C=CC=CC=1)([OH:3])=[O:2].[CH3:39][O:40][CH2:41][CH2:42][O:43][CH2:44][CH2:45][N+:46]1[C:54]2[C:49](=[CH:50][C:51]([S:55]([OH:58])(=[O:57])=[O:56])=[CH:52][CH:53]=2)[C:48]([CH3:66])([CH2:59][CH2:60][CH2:61][S:62]([OH:65])(=[O:64])=[O:63])[C:47]=1[CH3:67].C([O-])(=O)C.[Na+:72].C(OCC)C>C(O)(=O)C.C(OC(=O)C)(=O)C>[Na+:72].[Na+:72].[Na+:72].[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:15][CH:16]=2)[C:11]([CH3:29])([CH2:22][CH2:23][CH2:24][S:25]([OH:28])(=[O:26])=[O:27])/[C:10]/1=[CH:30]\[CH:31]=[CH:67]\[C:47]1[C:48]([CH3:66])([CH2:59][CH2:60][CH2:61][S:62]([OH:65])(=[O:64])=[O:63])[C:49]2[C:54](=[CH:53][CH:52]=[C:51]([S:55]([OH:58])(=[O:56])=[O:57])[CH:50]=2)[N+:46]=1[CH2:45][CH2:44][O:43][CH2:42][CH2:41][O:40][CH3:39])([OH:3])=[O:2]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 517045Sodium AcetateHCID 885363471-(5-carboxypentyl)-3-methyl-2-((E)-2-phenylamino-vinyl)-5-sulfo-3-(3-sulfopropyl)-3H-indoliumHCID 885363611-[2-(2-methoxy-ethoxy)-ethyl]-2,3-dimethyl-5-sulfo-3-(3-sulfopropyl)-3H-indolium3회

생성물 1

HCID 178496224HCID 178496224, 화합물

시약·촉매·용매 1

HCID 21895370AcOH AcOAc용매

실험 절차

Both 1 mmol 1-(5-carboxypentyl)-3-methyl-2-((E)-2-phenylamino-vinyl)-5-sulfo-3-(3-sulfopropyl)-3H-indolium and 1 mmol 1-[2-(2-methoxy-ethoxy)-ethyl]-2,3-dimethyl-5-sulfo-3-(3-sulfo-propyl)-3H-indolium were dissolved in 20 ml acetic acid/acetic anhydride (1/1) followed by the addition of 200 mg sodium acetate. The solution was stirred under reflux for 15 min. After cooling to room temperature, 20 ml diethylether was added. The resulting precipitate (mixture of the diastereomers 550-1 compound 2 and 550-2 compound 2) was extracted by suction, washed with ether and dried.

후처리

  1. temperatureunder reflux for 15 min
  2. extractionwas extracted by suction
  3. washwashed with ether
  4. customdried

출처 및 근거

ORD 기록
ord-82c41909fbb3492d95201c071bc38bf3
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889884B1

연결된 노트

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