Hexan-3-amine → N-(hexan-3-yl)-5-methoxybenzofuran-2-carboxamide

반응식

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([OH:13])=O)=[CH:8][C:7]=2[CH:14]=1.[CH3:15][CH2:16][CH:17]([NH2:21])[CH2:18][CH2:19][CH3:20]>>[CH3:15][CH2:16][CH:17]([NH:21][C:11]([C:9]1[O:10][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:14][C:7]=2[CH:8]=1)=[O:13])[CH2:18][CH2:19][CH3:20]

참가 물질

반응물 2

HCID 86062Hexan-3-amine

HCID 2886385-Methoxybenzofuran-2-carboxylic acid

생성물 1

HCID 57527859N-(hexan-3-yl)-5-methoxybenzofuran-2-carboxamide수율 32%

실험 절차

Prepared in a similar manner to example 4 using 5-methoxybenzofuran-2-carboxylic acid and hexan-3-amine (example 28a). Yield: 32%. 1H NMR (500 MHz, CDCl3): δ 0.96 (m, 6H); 1.40-1.67 (m, 6H); 3.85 (s, 3H); 4.09 (m, 1H); 6.28 (d, 1H); 7.01 (dd, 1H); 7.08 (d, 1H); 7.38 (m, 2H). MS (276, M+H).

출처 및 근거

ORD 기록: ord-fd3b7348bcb0425b8e085a8e87295180
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08895050B2

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