p-Toluic acid, 2,3,5,6-tetrafluoro- → (S)-2,3,5,6-tetrafluoro-4-methyl-N-(3-methylbutan-2-yl)benzamide

반응식

[CH3:1][CH:2]([CH3:6])[C@@H:3]([NH2:5])[CH3:4].[F:7][C:8]1[C:13]([F:14])=[C:12]([C:15](O)=[O:16])[C:11]([F:18])=[C:10]([F:19])[C:9]=1[CH3:20]>>[F:14][C:13]1[C:8]([F:7])=[C:9]([CH3:20])[C:10]([F:19])=[C:11]([F:18])[C:12]=1[C:15]([NH:5][C@H:3]([CH:2]([CH3:6])[CH3:1])[CH3:4])=[O:16]

참가 물질

반응물 2

HCID 69548p-Toluic acid, 2,3,5,6-tetrafluoro-

HCID 69997881,2-Dimethylpropylamine, (S)-

생성물 1

HCID 57527834(S)-2,3,5,6-tetrafluoro-4-methyl-N-(3-methylbutan-2-yl)benzamide

실험 절차

Prepared in a similar manner to Example 162 using (S)-3-methylbutan-2-amine and 2,3,5,6-tetrafluoro-p-toluic acid (93%). 1H NMR (CDCl3) δ 0.98 (d, J=6.9 Hz, 6H) 1.18 (d, J=6.8 Hz, 3H), 2.29 (m, 3H), 4.09 (m, 1H), 5.72 (bs, 1H). MS (304.1, M+H) m. p. 146-147° C.

출처 및 근거

ORD 기록: ord-c060f97583a9408c82625566748c06a3
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08895050B2

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