Thionyl Chloride → HCID 67240460, 화합물

HRID 339522

반응식

HRID 339522 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[C:5]([C:12]([F:15])([F:14])[F:13])[CH:4]=1.S(Cl)(Cl)=O.COC1C(C(F)(F)F)=CC(C(Cl)=O)=CC=1.[NH2:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[S:43][C:44]3[CH:50]=[C:49]([O:51][CH3:52])[CH:48]=[CH:47][C:45]=3[N:46]=2)=[CH:38][CH:37]=1>N1C=CC=CC=1>[F:13][C:12]([F:15])([F:14])[C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:6]=1[C:7]([NH:35][C:36]1[CH:37]=[CH:38][C:39]([C:42]2[S:43][C:44]3[CH:50]=[C:49]([O:51][CH3:52])[CH:48]=[CH:47][C:45]=3[N:46]=2)=[CH:40][CH:41]=1)=[O:9]

참가 물질

6

반응물 4

HCID 24386Thionyl ChlorideHCID 3918704-(6-Methoxy-1,3-benzothiazol-2-yl)anilineHCID 27752944-methoxy-2-(trifluoromethyl)benzoic AcidHCID 27752984-Methoxy-3-(trifluoromethyl)benzoyl chloride

생성물 1

HCID 67240460HCID 67240460, 화합물수율 46%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A stirred mixture of 4-methoxy-2-trifluoromethylbenzoic acid (0.50 g, 2.27 mmol) and thionyl chloride (9 ml) was heated under reflux for 4 h. After cooling to room temperature, the excess reagent was removed under reduced pressure to give crude acid chloride. The amide was prepared as described in the Amide Coupling section using the crude 4-methoxy-5-trifluoromethylbenzoyl chloride and 2-(4-aminophenyl)-6-methoxybenzo thiazole (0.58 g, 2.27 mmol) in dry pyridine (15 ml) to give the title compound (0.478 g, 46%) as pale yellow needles after work-up and recrystallisation from acetic acid.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 4 h
  3. customthe excess reagent was removed under reduced pressure
  4. customto give crude acid chloride
  5. customThe amide was prepared

출처 및 근거

ORD 기록
ord-d3daccfe68cc4410bdbac4b9d5eab2e2
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895313B2

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