Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Stannous chloride dihydrate → 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | 6-Methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine | HCID 749917 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | 58% |
반응 단계
Prepared as described in the Nitro Reduction section using 6-methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine (0.423 g, 1.67 mmol) and tin (II) chloride dihydrate (1.89 g, 8.36 mmol) in EtOH (45 ml) to give the title compound (0.216 g, 58%) as a pale orange solid, after work-up and flash chromatography (EtOAc).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895313B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-5cde5669826a48ddae31c560af713240 |
| 출처 메모 | uspto-grants-2014_11 |