Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Anisoyl chloride → 4-methoxy-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Anisoyl chloride | HCID 7477 | — |
| 반응물 | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 4-methoxy-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 42737530 | 79.3% |
반응 단계
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (70 mg, 0.314 mmol) and 4-methoxybenzoyl chloride (54 mg, 0.314 mmol) in dry pyridine (5 ml) to give the title compound (89 mg, 79%) as a pale yellow solid after work-up and flash chromatography (15:1 DCM/MeOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895313B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-f32acd5a5cf7436caa612378691cafef |
| 출처 메모 | uspto-grants-2014_11 |