4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline → 3,4,5-trifluoro-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide

HRID 339566

반응식

HRID 339566 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.[F:18][C:19]1[CH:20]=[C:21]([CH:25]=[C:26]([F:29])[C:27]=1[F:28])[C:22](Cl)=[O:23]>N1C=CC=CC=1>[F:18][C:19]1[CH:20]=[C:21]([CH:25]=[C:26]([F:29])[C:27]=1[F:28])[C:22]([NH:15][C:14]1[CH:16]=[CH:17][C:11]([C:9]2[N:10]=[C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]3[CH:8]=2)=[CH:12][CH:13]=1)=[O:23]

참가 물질

4

반응물 2

HCID 8210844-(6-Methylimidazo[1,2-a]pyridin-2-yl)anilineHCID 27770233,4,5-Trifluorobenzoyl chloride

생성물 1

HCID 583420973,4,5-trifluoro-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide수율 72.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (0.50 g, 2.24 mmol) and 3,4,5-trifluorobenzoyl chloride (0.436 g, 2.24 mmol) in dry pyridine (20 ml) to give the title compound (0.617 g, 72%) as a colourless solid, after work-up and recrystallisation from AcOH.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-3548273605754c7a846dcd694fa334af
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895313B2

연결된 노트

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