Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline → 3,4-difluoro-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| 반응물 | 3,4-Difluorobenzoyl chloride | HCID 2724519 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 3,4-difluoro-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 58341981 | 68.3% |
반응 단계
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (0.50 g, 2.24 mmol) and 3,4-difluorobenzoyl chloride (0.395 g, 2.24 mmol) in dry pyridine (20 ml) to give the title compound (0.556 g, 68%) as a colourless solid after work-up and recrystallisation from AcOH.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895313B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-c21d0de92fd043f18b71606ca72dbfaf |
| 출처 메모 | uspto-grants-2014_11 |