Ethanol → Ethyl 2-oxo-1-phenylpyrrolidine-3-carboxylate

HRID 339604노트

반응식

HRID 339604 반응식
S(Cl)(Cl)=O.[O:5]=[C:6]1[CH:10]([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][N:7]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH2:20](O)[CH3:21]>>[O:5]=[C:6]1[CH:10]([C:11]([O:13][CH2:20][CH3:21])=[O:12])[CH2:9][CH2:8][N:7]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 30437622-Oxo-1-phenylpyrrolidine-3-carboxylic acid

생성물 1

HCID 86700963Ethyl 2-oxo-1-phenylpyrrolidine-3-carboxylate수율 79%

반응 조건

온도
80 °C

실험 절차

Thionyl chloride is added at 0° C. (5.8 g) to a solution of 2-oxo-1-phenylpyrrolidine-3-carboxylic acid (5 g) in ethanol, and the batch is stirred at 80° C. for 4 h. When the reaction is complete, the batch is concentrated in vacuo, the residue is taken up in water and extracted with ethyl acetate. The organic phase is washed with saturated sodium bicarbonate solution and saturated sodium chloride solution and dried over sodium sulfate, giving ethyl 2-oxo-1-phenylpyrrolidine-3-carboxylate (4.5 g, 79%);

후처리

  1. concentrationthe batch is concentrated in vacuo
  2. extractionextracted with ethyl acetate
  3. washThe organic phase is washed with saturated sodium bicarbonate solution and saturated sodium chloride solution
  4. dry with materialdried over sodium sulfate

출처 및 근거

ORD 기록
ord-0bb585ce4b9e4890bac05b1936a9b8a1
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895535B2

반응 노트

불러오는 중…