Triethylamine → 3-Amino-2-oxo-1-phenylpyrrolidine-3-carboxylic acid (3-chloro-5-fluorobenzyl)amide

HRID 339605

반응식

HRID 339605 반응식
CCN(CC)CC.C(S)(S)CC.[Cl:13][C:14]1[CH:15]=[C:16]([CH:36]=[C:37]([F:39])[CH:38]=1)[CH2:17][NH:18][C:19]([C:21]1([N:33]=[N+]=[N-])[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:22]1=[O:32])=[O:20]>CO>[Cl:13][C:14]1[CH:15]=[C:16]([CH:36]=[C:37]([F:39])[CH:38]=1)[CH2:17][NH:18][C:19]([C:21]1([NH2:33])[CH2:25][CH2:24][N:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:22]1=[O:32])=[O:20]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 64285461,1-PropanedithiolHCID 867009653-Azido-2-oxo-1-phenylpyrrolidine-3-carboxylic acid (3-chloro-5-fluorobenzyl)amide

생성물 1

HCID 867009643-Amino-2-oxo-1-phenylpyrrolidine-3-carboxylic acid (3-chloro-5-fluorobenzyl)amide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Et3N (0.1 ml, 0.75 mmol) followed by propanedithiol (0.08 ml, 0.75 mmol) are added to a solution of 3-azido-2-oxo-1-phenylpyrrolidine-3-carboxylic acid (3-chloro-5-fluorobenzyl)amide (100 mg, 0.25 mmol) in 2 ml of methanol. The batch is stirred at RT for 12 hours. When the reaction is complete, all volatile constituents are removed in vacuo, and the residue is purified on silica gel.

후처리

  1. customall volatile constituents are removed in vacuo
  2. customthe residue is purified on silica gel

출처 및 근거

ORD 기록
ord-6d31dbd699b44efcac635c3acb941423
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895535B2

연결된 노트

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