Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic acid;iodosylbenzene → 8-(Tert-butyldimethylsilyloxy)-2-(7-(2-methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic acid;iodosylbenzene | HCID 73357407 | — |
| 반응물 | N-[(E)-[8-[tert-butyl(dimethyl)silyl]oxyquinolin-2-yl]methylideneamino]-4-(2-methoxyethoxy)pyridin-2-amine | HCID 173055441 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 8-(Tert-butyldimethylsilyloxy)-2-(7-(2-methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinoline | HCID 67231225 | 70% |
반응 단계
To a solution of (E)-8-(tert-butyldimethylsilyloxy)-2-((2-(4-(2-methoxyethoxy)pyridin-2-yl)hydrazono)methyl)quinoline (0.101 g, 0.223 mmol) in DCM (1.0 mL) was added iodosobenzene diacetate (0.0719 g, 0.223 mmol). After stirring at ambient temperature for 5 hours the reaction mixture was partitioned between DCM and aqueous saturated Na2S2O3. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified via flash column chromatography (40:1 DCM/MeOH) to provide 70 mg (70%) of desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895550B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-53fa496dba3f45c8aa2c6d6a827a1f5f |
| 출처 메모 | uspto-grants-2014_11 |