ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate → Ethyl 5-phenyl-1H-pyrrole-3-carboxylate

HRID 339726노트

반응식

HRID 339726 반응식
Cl[C:2]1[N:3](C)[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]>CO.[Pd]>[C:12]1([C:4]2[NH:3][CH:2]=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:5]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

4

반응물 1

HCID 11832263ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate

생성물 1

HCID 10242379Ethyl 5-phenyl-1H-pyrrole-3-carboxylate수율 97%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate (2.4 g, 9.1 mmol) and 10% Pd/C (100 mg) was dissolved in methanol (50 ml) at room temperature. The reaction mixture was hydrogenated for 6 hrs at room temperature and the resulting solution was filtered. After evaporated under reduced pressure, the residue was purified with normal phase preparative column chromatography to produce title compound (1.9g, 91%) as white solid.

후처리

  1. filtrationthe resulting solution was filtered
  2. customAfter evaporated under reduced pressure
  3. customthe residue was purified with normal phase preparative column chromatography

출처 및 근거

ORD 기록
ord-12bd385e253842538f585ceee5c28163
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895558B2

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