Water → HCID 58358814, 화합물

HRID 339729

반응식

HRID 339729 반응식
Cl.[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:23][CH2:24][N:25]1[C:33](=[O:34])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]1=[O:35].O>CN(C=O)C>[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:23][CH2:24][N:25]2[C:26](=[O:35])[C:27]3[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:33]2=[O:34])[CH2:12][CH2:11]1

참가 물질

6

반응물 4

HCID 962WaterHCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 11430Potassium CarbonateHCID 116303721-(2,3-Dichlorophenyl)piperazine hydrochloride

생성물 1

HCID 58358814HCID 58358814, 화합물수율 81.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1-(2,3-Dichlorophenyl)piperazine hydrochloride (3.16 g, 11.8 mmol) and potassium carbonate (4.08 g, 29.5 mmol) were added to the solution of 2-(2-bromoethyl)isoindoline-1,3-dione (3 g, 11.8 mmol) in DMF (20 ml). The reaction mixture was stirred for overnight at room temperature. After reaction complete, water (40 ml) was added and then normal work-up was taken. The residue was purified with normal phase preparative column to afford title compound (3.87 g, 81% yield) as white solid.

후처리

  1. customAfter reaction complete
  2. customThe residue was purified with normal phase preparative column

출처 및 근거

ORD 기록
ord-afbf9f4227bf4c2f89588f0c444cdc09
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895558B2

연결된 노트

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