Triethylamine → (R)-glycidyl methanesulfonate

HRID 339765노트

반응식

HRID 339765 반응식
[CH2:1]1[O:3][C@H:2]1[CH2:4][OH:5].C(N(CC)CC)C.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>CN(C=O)C>[CH3:13][S:14]([O:5][CH2:4][C@@H:2]1[O:3][CH2:1]1)(=[O:16])=[O:15]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 6973630(-)-Glycidol

생성물 1

HCID 12461091(R)-glycidyl methanesulfonate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

A solution of (S)-(−)-glycidol (8.6 mL, 130 mmol) and triethylamine (36.2 mL, 260 mmol, 2.0 equiv.) in DMF (250 mL) was cooled over an ice bath and methanesulfonyl chloride (10.1 mL, 130 mmol, 1.0 equiv.) was added dropwise. The mixture was stirred for 1.5 hr at room temperature affording a 0.47 M solution of (R)-glycidyl methanesulfonate in DMF, which was used without further purification.

출처 및 근거

ORD 기록
ord-2f9adc3493324321b07976fe9d19e93a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895549B2

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