Thionyl Chloride → HCID 86702828, 화합물

HRID 339774노트

반응식

HRID 339774 반응식
[N:1]1([CH2:7][C@H:8]([OH:11])[CH2:9][OH:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[S:12](Cl)([Cl:14])=[O:13]>C(Cl)Cl>[ClH:14].[O:13]=[S:12]1[O:11][C@@H:8]([CH2:7][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[CH2:9][O:10]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 1268043HCID 1268043, 화합물

생성물 1

HCID 86702828HCID 86702828, 화합물수율 103%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (2S)-3-(4-morpholinyl)-1,2-propanediol (0.90 g, 5.6 mmol) in CH2Cl2 (7.5 mL) was cooled to 0° C. and added thionyl chloride (0.81 mL, 11.1 mmol, 2.0 equiv.) was added dropwise. The resulting solution was heated at the reflux temperature for 1 hr, cooled to room temperature and concentrated under reduced pressure to give 4-[(4S)-(2-oxido-1,3,2-dioxathiolan-4-yl)methyl]morpholine hydrochloride (1.40 g, 103%). This material was used in the next step without further purification.

후처리

  1. additionwas added dropwise
  2. temperatureThe resulting solution was heated at the reflux temperature for 1 hr
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7311380053744fec9529076764c10dd8
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895549B2

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