Butanedione → HCID 178432401, 화합물

HRID 339799

반응식

HRID 339799 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[NH2:9].CC(=O)C(=[O:14])C.[C:16]1(C)C=C[CH:19]=[CH:18][CH:17]=1>CO>[CH3:16][C:17]1[N:9]=[C:3]2[C:4](=[N:8][C:18]=1[CH3:19])[N:5]=[CH:6][N:7]=[C:2]2[OH:14]

참가 물질

5

반응물 3

HCID 650ButanedioneHCID 1140TolueneHCID 780104,5-Pyrimidinediamine, 6-chloro-

생성물 1

HCID 178432401HCID 178432401, 화합물수율 72%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 6-chloropyrimidine-4,5-diamine (1.4 g, 10 mmol) and 2,3-butanedione (2.0 g, 23 mmol) in toluene (35 mL) and methanol (10 mL) was stirred at reflux for 1 h. Upon cooling, the product precipitated and was collected by suction filtration and rinsed with a MeOH/Et2O mixture (ca. 1:2), then air dried to afford 6,7-dimethylpteridin-4-ol (1.4 g, 72%) as a gold powder.

후처리

  1. temperatureat reflux for 1 h
  2. temperatureUpon cooling
  3. customthe product precipitated
  4. filtrationwas collected by suction filtration
  5. washrinsed with a MeOH/Et2O mixture (ca. 1:2)
  6. customair dried

출처 및 근거

ORD 기록
ord-cf819b3287c147ed84923bf362ed7613
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08895568B2

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